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Hot 100 number-one hits of 1966 (USA)
These are the Billboard magazine Hot 100 number one hits of 1966.
| Issue Date | Song | Artist |
| January 1 | The Sound of Silence | Simon and Garfunkel |
| January 8 | We Can Work It Out | The Beatles |
| January 15 | We Can Work It Out | The Beatles |
| January 22 | The Sound of Silence | Simon and Garfunkel |
| January 29 | We Can Work It Out | The Beatles |
| February 5 | My Love | Petula Clark |
| February 12 | My Love | Petula Clark |
| February 19 | Lightnin' Strikes | Lou Christie |
| February 26 | These Boots Are Made for Walkin' | Nancy Sinatra |
| March 5 | Ballad of the Green Berets | SSgt Barry Sadler |
| March 12 | Ballad of the Green Berets | SSgt Barry Sadler |
| March 19 | Ballad of the Green Berets | SSgt Barry Sadler |
| March 26 | Ballad of the Green Berets | SSgt Barry Sadler |
| April 2 | Ballad of the Green Berets | SSgt Barry Sadler |
| April 9 | (You're My) Soul and Inspiration | The Righteous Brothers |
| April 16 | (You're My) Soul and Inspiration | The Righteous Brothers |
| April 23 | (You're My) Soul and Inspiration | The Righteous Brothers |
| April 30 | Good Lovin' | The Young Rascals |
| May 7 | Monday, Monday | The Mamas and the Papas |
| May 14 | Monday, Monday | The Mamas and the Papas |
| May 21 | Monday, Monday | The Mamas and the Papas |
| May 28 | When a Man Loves a Woman | Percy Sledge |
| June 4 | When a Man Loves a Woman | Percy Sledge |
| June 11 | Paint It Black | The Rolling Stones |
| June 18 | Paint It Black | The Rolling Stones |
| June 25 | Paperback Writer | The Beatles |
| July 2 | Strangers in the Night | Frank Sinatra |
| July 9 | Paperback Writer | The Beatles |
| July 16 | Hanky Panky | Tommy James and the Shondells |
| July 23 | Hanky Panky | Tommy James and the Shondells |
| July 30 | Wild Thing | The Troggs |
| August 6 | Wild Thing | The Troggs |
| August 13 | Summer in the City | The Lovin' Spoonful |
| August 20 | Summer in the City | The Lovin' Spoonful |
| August 27 | Summer in the City | The Lovin' Spoonful |
| September 3 | Sunshine Superman | Donovan |
| September 10 | You Can't Hurry Love | The Supremes |
| September 17 | You Can't Hurry Love | The Supremes |
| September 24 | Cherish | The Association |
| October 1 | Cherish | The Association |
| October 8 | Cherish | The Association |
| October 15 | Reach Out I'll Be There | The Four Tops |
| October 22 | Reach Out I'll Be There | The Four Tops |
| October 29 | 96 Tears | ? and the Mysterians |
| November 5 | Last Train to Clarksville | The Monkees |
| November 12 | Poor Side of Town | Johnny Rivers |
| November 19 | You Keep Me Hangin' On | The Supremes |
| November 26 | You Keep Me Hangin' On | The Supremes |
| December 3 | Winchester Cathedral | The New Vaudeville Band |
| December 10 | Good Vibrations | The Beach Boys |
| December 17 | Winchester Cathedral | The New Vaudeville Band |
| December 24 | Winchester Cathedral | The New Vaudeville Band |
| December 31 | I'm a Believer | The Monkees |
