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Hot 100 number-one hits of 1978 (USA)
These are the Billboard magazine Hot 100 number one hits of 1978.
| Issue Date | Song | Artist |
| January 7 | How Deep Is Your Love (video) | Bee Gees |
| January 14 | Baby Come Back | Player |
| January 21 | Baby Come Back | Player |
| January 28 | Baby Come Back | Player |
| February 4 | Stayin' Alive | Bee Gees |
| February 11 | Stayin' Alive | Bee Gees |
| February 18 | Stayin' Alive | Bee Gees |
| February 25 | Stayin' Alive | Bee Gees |
| March 4 | (Love Is) Thicker Than Water | Andy Gibb |
| March 11 | (Love Is) Thicker Than Water | Andy Gibb |
| March 18 | Night Fever | Bee Gees |
| March 25 | Night Fever | Bee Gees |
| April 1 | Night Fever | Bee Gees |
| April 8 | Night Fever | Bee Gees |
| April 15 | Night Fever | Bee Gees |
| April 22 | Night Fever | Bee Gees |
| April 29 | Night Fever | Bee Gees |
| May 6 | Night Fever | Bee Gees |
| May 13 | If I Can't Have You | Yvonne Elliman |
| May 20 | With a Little Luck | Wings |
| May 27 | With a Little Luck | Wings |
| June 3 | Too Much, Too Little, Too Late | Johnny Mathis and Deniece Williams |
| June 10 | You're the One That I Want | John Travolta and Olivia Newton-John |
| June 17 | Shadow Dancing | Andy Gibb |
| June 24 | Shadow Dancing | Andy Gibb |
| July 1 | Shadow Dancing | Andy Gibb |
| July 8 | Shadow Dancing | Andy Gibb |
| July 15 | Shadow Dancing | Andy Gibb |
| July 22 | Shadow Dancing | Andy Gibb |
| July 29 | Shadow Dancing | Andy Gibb |
| August 5 | Miss You | The Rolling Stones |
| August 12 | Three Times a Lady | Commodores |
| August 19 | Three Times a Lady | Commodores |
| August 26 | Grease | Frankie Valli |
| September 2 | Grease | Frankie Valli |
| September 9 | Boogie Oogie Oogie | A Taste of Honey |
| September 16 | Boogie Oogie Oogie | A Taste of Honey |
| September 21 | Boogie Oogie Oogie | A Taste of Honey |
| September 28 | Kiss You All Over | Exile |
| October 7 | Kiss You All Over | Exile |
| October 14 | Kiss You All Over | Exile |
| October 21 | Kiss You All Over | Exile |
| October 28 | Hot Child in the City | Nick Gilder |
| November 4 | You Needed Me | Anne Murray |
| November 11 | MacArthur Park | Donna Summer |
| November 18 | MacArthur Park | Donna Summer |
| November 25 | MacArthur Park | Donna Summer |
| December 2 | You Don't Bring Me FloWers | Barbra Streisand and Neil Diamond |
| December 9 | Le Freak | CHIC |
| December 16 | You Don't Bring Me FloWers | Barbra Streisand and Neil Diamond |
| December 23 | Le Freak | CHIC |
| December 30 | Le Freak | CHIC |
