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Hot 100 number-one hits of 1991 (USA)
This is a list of the U.S. Billboard magazine Hot 100 number-ones of 1991.
| Issue Date | Song | Artist |
| January 5 | Justify My Love | Madonna |
| January 12 | Justify My Love | Madonna |
| > January 19 | Love Will Never Do (Without You) | Janet Jackson |
| January 26 | The First Time | Surface |
| February 2 | The First Time | Surface |
| February 9 | Gonna Make You SWeat (Everybody Dance Now) | CandC Music Factory featuring Freedom Williams |
| February 16 | Gonna Make You SWeat (Everybody Dance Now) | CandC Music Factory featuring Freedom Williams |
| February 23 | All the Man That I Need | Whitney Houston |
| March 2 | All the Man That I Need | Whitney Houston |
| March 9 | Someday | Mariah Carey |
| March 16 | Someday | Mariah Carey |
| March 23 | One More Try | Timmy T |
| March 30 | Coming Out of the Dark (video) | Gloria Estefan |
| April 6 | Coming Out of the Dark | Gloria Estefan |
| April 13 | I've Been Thinking About You (Video) | Londonbeat |
| April 20 | You're in Love | Wilson Phillips |
| April 27 | Baby Baby | Amy Grant |
| May 4 | Baby Baby | Amy Grant |
| May 11 | Joyride | Roxette |
| May 18 | I Like the Way (The Kissing Game) | Hi-Five |
| May 25 | I Don't Wanna Cry | Mariah Carey |
| June 1 | I Don't Wanna Cry | Mariah Carey |
| June 8 | More Than Words | Extreme |
| June 15 | Rush Rush | Paula Abdul |
| June 22 | Rush Rush | Paula Abdul |
| June 29 | Rush Rush | Paula Abdul |
| July 6 | Rush Rush | Paula Abdul |
| July 13 | Rush Rush | Paula Abdul |
| July 20 | Unbelievable | EMF |
| July 27 | (Everything I Do) I Do It for You (video) | Bryan Adams |
| August 3 | (Everything I Do) I Do It for You | Bryan Adams |
| August 10 | (Everything I Do) I Do It for You | Bryan Adams |
| August 17 | (Everything I Do) I Do It for You | Bryan Adams |
| August 24 | (Everything I Do) I Do It for You | Bryan Adams |
| August 31 | (Everything I Do) I Do It for You | Bryan Adams |
| September 7 | (Everything I Do) I Do It for You | Bryan Adams |
| September 14 | The Promise of a New Day | Paula Abdul |
| September 21 | I Adore Mi Amor | Color Me Badd |
| September 28 | I Adore Mi Amor | Color Me Badd |
| October 5 | Good Vibrations | Marky Mark and the Funky Bunch featuring Loleatta Holloway |
| October 12 | Emotions | Mariah Carey |
| October 19 | Emotions | Mariah Carey |
| October 26 | Emotions | Mariah Carey |
| November 2 | Romantic | Karyn White |
| November 9 | Cream | Prince and the New PoWer Generation |
| November 16 | Cream | Prince and the New PoWer Generation |
| November 23 | When a Man Loves a Woman | Michael Bolton |
| November 30 | Set Adrift on Memory Bliss | P.M. Dawn |
| December 7 | Black or White | Michael Jackson |
| December 14 | Black or White | Michael Jackson |
| December 21 | Black or White | Michael Jackson |
| December 28 | Black or White | Michael Jackson |
